UnivTrevesV1, Main, Exploration, bibRecord, 000239

Polymorphisms in genes involved in EGFR-turnover are predictive for cetuximab efficacy in colorectal cancer

Identifieur interne : 000239 ( Main/Exploration ); précédent : 000238; suivant : 000240

Polymorphisms in genes involved in EGFR-turnover are predictive for cetuximab efficacy in colorectal cancer

Auteurs : Sebastian Stintzing [Allemagne] ; Wu Zhang ; Volker Heinemann [Allemagne] ; Daniel Neureiter [Autriche] ; Ralf Kemmerling [Autriche, Allemagne] ; Thomas Kirchner [Allemagne] ; Andreas Jung [Allemagne] ; Matthias Folwaczny [Allemagne] ; Dongyun Yang [États-Unis] ; Yan Ning ; Ana Sebio [Espagne] ; Stefan Stremitzer ; Yu Sunakawa ; Satoshi Matsusaka ; Shinichi Yamauchi ; Fotios Loupakis [Italie] ; Chiara Cremolini [Italie] ; Alfredo Falcone [Italie] ; Heinz-Josef Lenz [États-Unis]

Source :

Molecular cancer therapeutics [ 1535-7163 ] ; 2015.

RBID : PMC:4596768

English descriptors

KwdEn :
- Adenocarcinoma (drug therapy), Adenocarcinoma (genetics), Adenocarcinoma (mortality), Adenocarcinoma (secondary), Adult, Aged, Aged, 80 and over, Antineoplastic Agents (pharmacology), Antineoplastic Agents (therapeutic use), Antineoplastic Combined Chemotherapy Protocols (therapeutic use), Camptothecin (analogs & derivatives), Camptothecin (therapeutic use), Case-Control Studies, Cetuximab (pharmacology), Cetuximab (therapeutic use), Colorectal Neoplasms (drug therapy), Colorectal Neoplasms (genetics), Colorectal Neoplasms (mortality), Colorectal Neoplasms (pathology), Disease-Free Survival, Drug Resistance, Neoplasm, Female, Fluorouracil (therapeutic use), Gene Frequency, Genetic Association Studies, Humans, Kaplan-Meier Estimate, Leucovorin (therapeutic use), Male, Middle Aged, Polymorphism, Single Nucleotide, Proteolysis, Receptor, Epidermal Growth Factor (metabolism), Treatment Outcome, Ubiquitin-Conjugating Enzymes (genetics), Ubiquitination.
MESH :
- chemical , analogs & derivatives : Camptothecin.
- chemical , genetics : Ubiquitin-Conjugating Enzymes.
- chemical , metabolism : Receptor, Epidermal Growth Factor.
- chemical , pharmacology : Antineoplastic Agents, Cetuximab.
- drug therapy : Adenocarcinoma, Colorectal Neoplasms.
- genetics : Adenocarcinoma, Colorectal Neoplasms.
- mortality : Adenocarcinoma, Colorectal Neoplasms.
- pathology : Colorectal Neoplasms.
- secondary : Adenocarcinoma.
- chemical , therapeutic use : Antineoplastic Agents, Antineoplastic Combined Chemotherapy Protocols, Camptothecin, Cetuximab, Fluorouracil, Leucovorin.
- Adult, Aged, Aged, 80 and over, Case-Control Studies, Disease-Free Survival, Drug Resistance, Neoplasm, Female, Gene Frequency, Genetic Association Studies, Humans, Kaplan-Meier Estimate, Male, Middle Aged, Polymorphism, Single Nucleotide, Proteolysis, Treatment Outcome, Ubiquitination.

Abstract

Transmembrane receptors such as the epidermal growth factor receptor (EGFR) are regulated by their turnover, which is dependent on the ubiquitin-proteasome-system (UPS). We tested in two independent study cohorts whether single nucleotide polymorphisms (SNPs) in genes involved in EGFR turnover predict clinical outcome in cetuximab treated metastatic colorectal cancer patients. The following SNPs involved in EGFR degradation were analyzed in a screening cohort of 108 patients treated with cetuximab in the chemorefractory setting: c-CBL (rs7105971; rs4938637; rs4938638; rs251837), EPS15 (rs17567; rs7308; rs1065754), NAE1 (rs363169; rs363170; rs363172); SH3KBP1 (rs7051590; rs5955820; rs1017874; rs11795873); SGIP1 (rs604737; rs6570808; rs7526812); UBE2M (rs895364; rs895374); UBE2L3 (rs5754216). SNPs showing an association with response or survival were analyzed in BRAF and RAS wild-type samples from the FIRE-3 study. 153 FOLFIRI plus cetuximab treated patients served as validation set, 168 patients of the FOLFIRI plus bevacizumab arm served as controls. EGFR FISH was done in 138 samples to test whether significant SNPs were associated with EGFR expression. UBE2M rs895374 was significantly associated with PFS (logrank-p = 0.005; HR 0.60) within cetuximab treated patients. No association with bevacizumab treated patients (n=168) could be established (p= 0.56, HR: 0.90). rs895374 genotype did not affect EGFR FISH measurements. EGFR recycling is an interesting mechanism of secondary resistance to cetuximab in mCRC. This is the first report suggesting that germline polymorphisms in the degradation process predict efficacy of cetuximab in patients with mCRC. Genes involved in EGFR turnover may be new targets in the treatment of mCRC.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4596768

DOI: 10.1158/1535-7163.MCT-15-0121
PubMed: 26206335
PubMed Central: 4596768

Affiliations:

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Polymorphisms in genes involved in EGFR-turnover are predictive for cetuximab efficacy in colorectal cancer</title>
<author><name sortKey="Stintzing, Sebastian" sort="Stintzing, Sebastian" uniqKey="Stintzing S" first="Sebastian" last="Stintzing">Sebastian Stintzing</name>
<affiliation><nlm:aff id="A1"> USC/Norris Comprehensive Cancer Center, Keck School of Medicine, Sharon Carpenter Laboratory</nlm:aff>
<wicri:noCountry code="subfield">Sharon Carpenter Laboratory</wicri:noCountry>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="A2"> Department for Medical Oncology and Comprehensive Cancer Center, University of Munich, Munich, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea> Department for Medical Oncology and Comprehensive Cancer Center, University of Munich, Munich</wicri:regionArea>
<placeName><region type="land" nuts="1">Bavière</region>
<region type="district" nuts="2">District de Haute-Bavière</region>
<settlement type="city">Munich</settlement>
</placeName>
<orgName type="university">Université Louis-et-Maximilien de Munich</orgName>
</affiliation>
</author>
<author><name sortKey="Zhang, Wu" sort="Zhang, Wu" uniqKey="Zhang W" first="Wu" last="Zhang">Wu Zhang</name>
<affiliation><nlm:aff id="A1"> USC/Norris Comprehensive Cancer Center, Keck School of Medicine, Sharon Carpenter Laboratory</nlm:aff>
<wicri:noCountry code="subfield">Sharon Carpenter Laboratory</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Heinemann, Volker" sort="Heinemann, Volker" uniqKey="Heinemann V" first="Volker" last="Heinemann">Volker Heinemann</name>
<affiliation wicri:level="4"><nlm:aff id="A2"> Department for Medical Oncology and Comprehensive Cancer Center, University of Munich, Munich, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea> Department for Medical Oncology and Comprehensive Cancer Center, University of Munich, Munich</wicri:regionArea>
<placeName><region type="land" nuts="1">Bavière</region>
<region type="district" nuts="2">District de Haute-Bavière</region>
<settlement type="city">Munich</settlement>
</placeName>
<orgName type="university">Université Louis-et-Maximilien de Munich</orgName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A3"> German Cancer Consortium (DKTK); German Cancer Research Centre (DKFZ), Heidelberg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea> German Cancer Consortium (DKTK); German Cancer Research Centre (DKFZ), Heidelberg</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Karlsruhe</region>
<settlement type="city">Heidelberg</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Neureiter, Daniel" sort="Neureiter, Daniel" uniqKey="Neureiter D" first="Daniel" last="Neureiter">Daniel Neureiter</name>
<affiliation wicri:level="1"><nlm:aff id="A4"> Institute of Pathology, SALK and Medical University of Salzburg, Austria</nlm:aff>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea> Institute of Pathology, SALK and Medical University of Salzburg</wicri:regionArea>
<wicri:noRegion>SALK and Medical University of Salzburg</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kemmerling, Ralf" sort="Kemmerling, Ralf" uniqKey="Kemmerling R" first="Ralf" last="Kemmerling">Ralf Kemmerling</name>
<affiliation wicri:level="1"><nlm:aff id="A4"> Institute of Pathology, SALK and Medical University of Salzburg, Austria</nlm:aff>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea> Institute of Pathology, SALK and Medical University of Salzburg</wicri:regionArea>
<wicri:noRegion>SALK and Medical University of Salzburg</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A5"> Medizinisches Versorgungszentrum für Histologie, Zytologie und Molekulare Diagnostik, Trier, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea> Medizinisches Versorgungszentrum für Histologie, Zytologie und Molekulare Diagnostik, Trier</wicri:regionArea>
<wicri:noRegion>Trier</wicri:noRegion>
<wicri:noRegion>Trier</wicri:noRegion>
<wicri:noRegion>Trier</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kirchner, Thomas" sort="Kirchner, Thomas" uniqKey="Kirchner T" first="Thomas" last="Kirchner">Thomas Kirchner</name>
<affiliation wicri:level="3"><nlm:aff id="A3"> German Cancer Consortium (DKTK); German Cancer Research Centre (DKFZ), Heidelberg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea> German Cancer Consortium (DKTK); German Cancer Research Centre (DKFZ), Heidelberg</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Karlsruhe</region>
<settlement type="city">Heidelberg</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="A6"> Institute of Pathology, University of Munich, Munich, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea> Institute of Pathology, University of Munich, Munich</wicri:regionArea>
<placeName><region type="land" nuts="1">Bavière</region>
<region type="district" nuts="2">District de Haute-Bavière</region>
<settlement type="city">Munich</settlement>
</placeName>
<orgName type="university">Université Louis-et-Maximilien de Munich</orgName>
</affiliation>
</author>
<author><name sortKey="Jung, Andreas" sort="Jung, Andreas" uniqKey="Jung A" first="Andreas" last="Jung">Andreas Jung</name>
<affiliation wicri:level="4"><nlm:aff id="A6"> Institute of Pathology, University of Munich, Munich, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea> Institute of Pathology, University of Munich, Munich</wicri:regionArea>
<placeName><region type="land" nuts="1">Bavière</region>
<region type="district" nuts="2">District de Haute-Bavière</region>
<settlement type="city">Munich</settlement>
</placeName>
<orgName type="university">Université Louis-et-Maximilien de Munich</orgName>
</affiliation>
</author>
<author><name sortKey="Folwaczny, Matthias" sort="Folwaczny, Matthias" uniqKey="Folwaczny M" first="Matthias" last="Folwaczny">Matthias Folwaczny</name>
<affiliation wicri:level="4"><nlm:aff id="A7"> Department of Preventive Dentistry and Periodontology, University of Munich, Munich, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea> Department of Preventive Dentistry and Periodontology, University of Munich, Munich</wicri:regionArea>
<placeName><region type="land" nuts="1">Bavière</region>
<region type="district" nuts="2">District de Haute-Bavière</region>
<settlement type="city">Munich</settlement>
</placeName>
<orgName type="university">Université Louis-et-Maximilien de Munich</orgName>
</affiliation>
</author>
<author><name sortKey="Yang, Dongyun" sort="Yang, Dongyun" uniqKey="Yang D" first="Dongyun" last="Yang">Dongyun Yang</name>
<affiliation wicri:level="2"><nlm:aff id="A8"> Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California</nlm:aff>
<country>États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea> Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Ning, Yan" sort="Ning, Yan" uniqKey="Ning Y" first="Yan" last="Ning">Yan Ning</name>
<affiliation><nlm:aff id="A1"> USC/Norris Comprehensive Cancer Center, Keck School of Medicine, Sharon Carpenter Laboratory</nlm:aff>
<wicri:noCountry code="subfield">Sharon Carpenter Laboratory</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Sebio, Ana" sort="Sebio, Ana" uniqKey="Sebio A" first="Ana" last="Sebio">Ana Sebio</name>
<affiliation><nlm:aff id="A1"> USC/Norris Comprehensive Cancer Center, Keck School of Medicine, Sharon Carpenter Laboratory</nlm:aff>
<wicri:noCountry code="subfield">Sharon Carpenter Laboratory</wicri:noCountry>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A9"> Hospital de la Santa Creu i Sant Pau, Barcelona, Spain</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea> Hospital de la Santa Creu i Sant Pau, Barcelona</wicri:regionArea>
<placeName><settlement type="city">Barcelone</settlement>
<region nuts="2" type="region">Catalogne</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Stremitzer, Stefan" sort="Stremitzer, Stefan" uniqKey="Stremitzer S" first="Stefan" last="Stremitzer">Stefan Stremitzer</name>
<affiliation><nlm:aff id="A1"> USC/Norris Comprehensive Cancer Center, Keck School of Medicine, Sharon Carpenter Laboratory</nlm:aff>
<wicri:noCountry code="subfield">Sharon Carpenter Laboratory</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Sunakawa, Yu" sort="Sunakawa, Yu" uniqKey="Sunakawa Y" first="Yu" last="Sunakawa">Yu Sunakawa</name>
<affiliation><nlm:aff id="A1"> USC/Norris Comprehensive Cancer Center, Keck School of Medicine, Sharon Carpenter Laboratory</nlm:aff>
<wicri:noCountry code="subfield">Sharon Carpenter Laboratory</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Matsusaka, Satoshi" sort="Matsusaka, Satoshi" uniqKey="Matsusaka S" first="Satoshi" last="Matsusaka">Satoshi Matsusaka</name>
<affiliation><nlm:aff id="A1"> USC/Norris Comprehensive Cancer Center, Keck School of Medicine, Sharon Carpenter Laboratory</nlm:aff>
<wicri:noCountry code="subfield">Sharon Carpenter Laboratory</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Yamauchi, Shinichi" sort="Yamauchi, Shinichi" uniqKey="Yamauchi S" first="Shinichi" last="Yamauchi">Shinichi Yamauchi</name>
<affiliation><nlm:aff id="A1"> USC/Norris Comprehensive Cancer Center, Keck School of Medicine, Sharon Carpenter Laboratory</nlm:aff>
<wicri:noCountry code="subfield">Sharon Carpenter Laboratory</wicri:noCountry>
</affiliation>
<affiliation><nlm:aff id="A10"> Graduate School, Tokyo Medical and Dental University, Tokyo Japan</nlm:aff>
<wicri:noCountry code="subfield">Tokyo Japan</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Loupakis, Fotios" sort="Loupakis, Fotios" uniqKey="Loupakis F" first="Fotios" last="Loupakis">Fotios Loupakis</name>
<affiliation wicri:level="3"><nlm:aff id="A11"> U.O. Oncologia Medica 2 – Aziendo Ospedaliero-Universitaria Pisana, Pisa, Italy</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea> U.O. Oncologia Medica 2 – Aziendo Ospedaliero-Universitaria Pisana, Pisa</wicri:regionArea>
<placeName><settlement type="city">Pise</settlement>
<region nuts="2">Toscane</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Cremolini, Chiara" sort="Cremolini, Chiara" uniqKey="Cremolini C" first="Chiara" last="Cremolini">Chiara Cremolini</name>
<affiliation wicri:level="3"><nlm:aff id="A11"> U.O. Oncologia Medica 2 – Aziendo Ospedaliero-Universitaria Pisana, Pisa, Italy</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea> U.O. Oncologia Medica 2 – Aziendo Ospedaliero-Universitaria Pisana, Pisa</wicri:regionArea>
<placeName><settlement type="city">Pise</settlement>
<region nuts="2">Toscane</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Falcone, Alfredo" sort="Falcone, Alfredo" uniqKey="Falcone A" first="Alfredo" last="Falcone">Alfredo Falcone</name>
<affiliation wicri:level="3"><nlm:aff id="A11"> U.O. Oncologia Medica 2 – Aziendo Ospedaliero-Universitaria Pisana, Pisa, Italy</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea> U.O. Oncologia Medica 2 – Aziendo Ospedaliero-Universitaria Pisana, Pisa</wicri:regionArea>
<placeName><settlement type="city">Pise</settlement>
<region nuts="2">Toscane</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Lenz, Heinz Josef" sort="Lenz, Heinz Josef" uniqKey="Lenz H" first="Heinz-Josef" last="Lenz">Heinz-Josef Lenz</name>
<affiliation><nlm:aff id="A1"> USC/Norris Comprehensive Cancer Center, Keck School of Medicine, Sharon Carpenter Laboratory</nlm:aff>
<wicri:noCountry code="subfield">Sharon Carpenter Laboratory</wicri:noCountry>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A8"> Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California</nlm:aff>
<country>États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea> Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles</wicri:cityArea>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">26206335</idno>
<idno type="pmc">4596768</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4596768</idno>
<idno type="RBID">PMC:4596768</idno>
<idno type="doi">10.1158/1535-7163.MCT-15-0121</idno>
<date when="2015">2015</date>
<idno type="wicri:Area/Pmc/Corpus">000129</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000129</idno>
<idno type="wicri:Area/Pmc/Curation">000129</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000129</idno>
<idno type="wicri:Area/Pmc/Checkpoint">000031</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000031</idno>
<idno type="wicri:source">PubMed</idno>
<idno type="wicri:Area/PubMed/Corpus">000226</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000226</idno>
<idno type="wicri:Area/PubMed/Curation">000226</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000226</idno>
<idno type="wicri:Area/PubMed/Checkpoint">000226</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000226</idno>
<idno type="wicri:Area/Ncbi/Merge">000805</idno>
<idno type="wicri:Area/Ncbi/Curation">000805</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">000805</idno>
<idno type="wicri:doubleKey">1535-7163:2015:Stintzing S:polymorphisms:in:genes</idno>
<idno type="wicri:Area/Main/Merge">000239</idno>
<idno type="wicri:Area/Main/Curation">000239</idno>
<idno type="wicri:Area/Main/Exploration">000239</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Polymorphisms in genes involved in EGFR-turnover are predictive for cetuximab efficacy in colorectal cancer</title>
<author><name sortKey="Stintzing, Sebastian" sort="Stintzing, Sebastian" uniqKey="Stintzing S" first="Sebastian" last="Stintzing">Sebastian Stintzing</name>
<affiliation><nlm:aff id="A1"> USC/Norris Comprehensive Cancer Center, Keck School of Medicine, Sharon Carpenter Laboratory</nlm:aff>
<wicri:noCountry code="subfield">Sharon Carpenter Laboratory</wicri:noCountry>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="A2"> Department for Medical Oncology and Comprehensive Cancer Center, University of Munich, Munich, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea> Department for Medical Oncology and Comprehensive Cancer Center, University of Munich, Munich</wicri:regionArea>
<placeName><region type="land" nuts="1">Bavière</region>
<region type="district" nuts="2">District de Haute-Bavière</region>
<settlement type="city">Munich</settlement>
</placeName>
<orgName type="university">Université Louis-et-Maximilien de Munich</orgName>
</affiliation>
</author>
<author><name sortKey="Zhang, Wu" sort="Zhang, Wu" uniqKey="Zhang W" first="Wu" last="Zhang">Wu Zhang</name>
<affiliation><nlm:aff id="A1"> USC/Norris Comprehensive Cancer Center, Keck School of Medicine, Sharon Carpenter Laboratory</nlm:aff>
<wicri:noCountry code="subfield">Sharon Carpenter Laboratory</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Heinemann, Volker" sort="Heinemann, Volker" uniqKey="Heinemann V" first="Volker" last="Heinemann">Volker Heinemann</name>
<affiliation wicri:level="4"><nlm:aff id="A2"> Department for Medical Oncology and Comprehensive Cancer Center, University of Munich, Munich, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea> Department for Medical Oncology and Comprehensive Cancer Center, University of Munich, Munich</wicri:regionArea>
<placeName><region type="land" nuts="1">Bavière</region>
<region type="district" nuts="2">District de Haute-Bavière</region>
<settlement type="city">Munich</settlement>
</placeName>
<orgName type="university">Université Louis-et-Maximilien de Munich</orgName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A3"> German Cancer Consortium (DKTK); German Cancer Research Centre (DKFZ), Heidelberg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea> German Cancer Consortium (DKTK); German Cancer Research Centre (DKFZ), Heidelberg</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Karlsruhe</region>
<settlement type="city">Heidelberg</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Neureiter, Daniel" sort="Neureiter, Daniel" uniqKey="Neureiter D" first="Daniel" last="Neureiter">Daniel Neureiter</name>
<affiliation wicri:level="1"><nlm:aff id="A4"> Institute of Pathology, SALK and Medical University of Salzburg, Austria</nlm:aff>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea> Institute of Pathology, SALK and Medical University of Salzburg</wicri:regionArea>
<wicri:noRegion>SALK and Medical University of Salzburg</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kemmerling, Ralf" sort="Kemmerling, Ralf" uniqKey="Kemmerling R" first="Ralf" last="Kemmerling">Ralf Kemmerling</name>
<affiliation wicri:level="1"><nlm:aff id="A4"> Institute of Pathology, SALK and Medical University of Salzburg, Austria</nlm:aff>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea> Institute of Pathology, SALK and Medical University of Salzburg</wicri:regionArea>
<wicri:noRegion>SALK and Medical University of Salzburg</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A5"> Medizinisches Versorgungszentrum für Histologie, Zytologie und Molekulare Diagnostik, Trier, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea> Medizinisches Versorgungszentrum für Histologie, Zytologie und Molekulare Diagnostik, Trier</wicri:regionArea>
<wicri:noRegion>Trier</wicri:noRegion>
<wicri:noRegion>Trier</wicri:noRegion>
<wicri:noRegion>Trier</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kirchner, Thomas" sort="Kirchner, Thomas" uniqKey="Kirchner T" first="Thomas" last="Kirchner">Thomas Kirchner</name>
<affiliation wicri:level="3"><nlm:aff id="A3"> German Cancer Consortium (DKTK); German Cancer Research Centre (DKFZ), Heidelberg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea> German Cancer Consortium (DKTK); German Cancer Research Centre (DKFZ), Heidelberg</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Karlsruhe</region>
<settlement type="city">Heidelberg</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="A6"> Institute of Pathology, University of Munich, Munich, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea> Institute of Pathology, University of Munich, Munich</wicri:regionArea>
<placeName><region type="land" nuts="1">Bavière</region>
<region type="district" nuts="2">District de Haute-Bavière</region>
<settlement type="city">Munich</settlement>
</placeName>
<orgName type="university">Université Louis-et-Maximilien de Munich</orgName>
</affiliation>
</author>
<author><name sortKey="Jung, Andreas" sort="Jung, Andreas" uniqKey="Jung A" first="Andreas" last="Jung">Andreas Jung</name>
<affiliation wicri:level="4"><nlm:aff id="A6"> Institute of Pathology, University of Munich, Munich, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea> Institute of Pathology, University of Munich, Munich</wicri:regionArea>
<placeName><region type="land" nuts="1">Bavière</region>
<region type="district" nuts="2">District de Haute-Bavière</region>
<settlement type="city">Munich</settlement>
</placeName>
<orgName type="university">Université Louis-et-Maximilien de Munich</orgName>
</affiliation>
</author>
<author><name sortKey="Folwaczny, Matthias" sort="Folwaczny, Matthias" uniqKey="Folwaczny M" first="Matthias" last="Folwaczny">Matthias Folwaczny</name>
<affiliation wicri:level="4"><nlm:aff id="A7"> Department of Preventive Dentistry and Periodontology, University of Munich, Munich, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea> Department of Preventive Dentistry and Periodontology, University of Munich, Munich</wicri:regionArea>
<placeName><region type="land" nuts="1">Bavière</region>
<region type="district" nuts="2">District de Haute-Bavière</region>
<settlement type="city">Munich</settlement>
</placeName>
<orgName type="university">Université Louis-et-Maximilien de Munich</orgName>
</affiliation>
</author>
<author><name sortKey="Yang, Dongyun" sort="Yang, Dongyun" uniqKey="Yang D" first="Dongyun" last="Yang">Dongyun Yang</name>
<affiliation wicri:level="2"><nlm:aff id="A8"> Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California</nlm:aff>
<country>États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea> Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Ning, Yan" sort="Ning, Yan" uniqKey="Ning Y" first="Yan" last="Ning">Yan Ning</name>
<affiliation><nlm:aff id="A1"> USC/Norris Comprehensive Cancer Center, Keck School of Medicine, Sharon Carpenter Laboratory</nlm:aff>
<wicri:noCountry code="subfield">Sharon Carpenter Laboratory</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Sebio, Ana" sort="Sebio, Ana" uniqKey="Sebio A" first="Ana" last="Sebio">Ana Sebio</name>
<affiliation><nlm:aff id="A1"> USC/Norris Comprehensive Cancer Center, Keck School of Medicine, Sharon Carpenter Laboratory</nlm:aff>
<wicri:noCountry code="subfield">Sharon Carpenter Laboratory</wicri:noCountry>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A9"> Hospital de la Santa Creu i Sant Pau, Barcelona, Spain</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea> Hospital de la Santa Creu i Sant Pau, Barcelona</wicri:regionArea>
<placeName><settlement type="city">Barcelone</settlement>
<region nuts="2" type="region">Catalogne</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Stremitzer, Stefan" sort="Stremitzer, Stefan" uniqKey="Stremitzer S" first="Stefan" last="Stremitzer">Stefan Stremitzer</name>
<affiliation><nlm:aff id="A1"> USC/Norris Comprehensive Cancer Center, Keck School of Medicine, Sharon Carpenter Laboratory</nlm:aff>
<wicri:noCountry code="subfield">Sharon Carpenter Laboratory</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Sunakawa, Yu" sort="Sunakawa, Yu" uniqKey="Sunakawa Y" first="Yu" last="Sunakawa">Yu Sunakawa</name>
<affiliation><nlm:aff id="A1"> USC/Norris Comprehensive Cancer Center, Keck School of Medicine, Sharon Carpenter Laboratory</nlm:aff>
<wicri:noCountry code="subfield">Sharon Carpenter Laboratory</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Matsusaka, Satoshi" sort="Matsusaka, Satoshi" uniqKey="Matsusaka S" first="Satoshi" last="Matsusaka">Satoshi Matsusaka</name>
<affiliation><nlm:aff id="A1"> USC/Norris Comprehensive Cancer Center, Keck School of Medicine, Sharon Carpenter Laboratory</nlm:aff>
<wicri:noCountry code="subfield">Sharon Carpenter Laboratory</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Yamauchi, Shinichi" sort="Yamauchi, Shinichi" uniqKey="Yamauchi S" first="Shinichi" last="Yamauchi">Shinichi Yamauchi</name>
<affiliation><nlm:aff id="A1"> USC/Norris Comprehensive Cancer Center, Keck School of Medicine, Sharon Carpenter Laboratory</nlm:aff>
<wicri:noCountry code="subfield">Sharon Carpenter Laboratory</wicri:noCountry>
</affiliation>
<affiliation><nlm:aff id="A10"> Graduate School, Tokyo Medical and Dental University, Tokyo Japan</nlm:aff>
<wicri:noCountry code="subfield">Tokyo Japan</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Loupakis, Fotios" sort="Loupakis, Fotios" uniqKey="Loupakis F" first="Fotios" last="Loupakis">Fotios Loupakis</name>
<affiliation wicri:level="3"><nlm:aff id="A11"> U.O. Oncologia Medica 2 – Aziendo Ospedaliero-Universitaria Pisana, Pisa, Italy</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea> U.O. Oncologia Medica 2 – Aziendo Ospedaliero-Universitaria Pisana, Pisa</wicri:regionArea>
<placeName><settlement type="city">Pise</settlement>
<region nuts="2">Toscane</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Cremolini, Chiara" sort="Cremolini, Chiara" uniqKey="Cremolini C" first="Chiara" last="Cremolini">Chiara Cremolini</name>
<affiliation wicri:level="3"><nlm:aff id="A11"> U.O. Oncologia Medica 2 – Aziendo Ospedaliero-Universitaria Pisana, Pisa, Italy</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea> U.O. Oncologia Medica 2 – Aziendo Ospedaliero-Universitaria Pisana, Pisa</wicri:regionArea>
<placeName><settlement type="city">Pise</settlement>
<region nuts="2">Toscane</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Falcone, Alfredo" sort="Falcone, Alfredo" uniqKey="Falcone A" first="Alfredo" last="Falcone">Alfredo Falcone</name>
<affiliation wicri:level="3"><nlm:aff id="A11"> U.O. Oncologia Medica 2 – Aziendo Ospedaliero-Universitaria Pisana, Pisa, Italy</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea> U.O. Oncologia Medica 2 – Aziendo Ospedaliero-Universitaria Pisana, Pisa</wicri:regionArea>
<placeName><settlement type="city">Pise</settlement>
<region nuts="2">Toscane</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Lenz, Heinz Josef" sort="Lenz, Heinz Josef" uniqKey="Lenz H" first="Heinz-Josef" last="Lenz">Heinz-Josef Lenz</name>
<affiliation><nlm:aff id="A1"> USC/Norris Comprehensive Cancer Center, Keck School of Medicine, Sharon Carpenter Laboratory</nlm:aff>
<wicri:noCountry code="subfield">Sharon Carpenter Laboratory</wicri:noCountry>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A8"> Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California</nlm:aff>
<country>États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea> Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles</wicri:cityArea>
</affiliation>
</author>
</analytic>
<series><title level="j">Molecular cancer therapeutics</title>
<idno type="ISSN">1535-7163</idno>
<idno type="eISSN">1538-8514</idno>
<imprint><date when="2015">2015</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adenocarcinoma (drug therapy)</term>
<term>Adenocarcinoma (genetics)</term>
<term>Adenocarcinoma (mortality)</term>
<term>Adenocarcinoma (secondary)</term>
<term>Adult</term>
<term>Aged</term>
<term>Aged, 80 and over</term>
<term>Antineoplastic Agents (pharmacology)</term>
<term>Antineoplastic Agents (therapeutic use)</term>
<term>Antineoplastic Combined Chemotherapy Protocols (therapeutic use)</term>
<term>Camptothecin (analogs & derivatives)</term>
<term>Camptothecin (therapeutic use)</term>
<term>Case-Control Studies</term>
<term>Cetuximab (pharmacology)</term>
<term>Cetuximab (therapeutic use)</term>
<term>Colorectal Neoplasms (drug therapy)</term>
<term>Colorectal Neoplasms (genetics)</term>
<term>Colorectal Neoplasms (mortality)</term>
<term>Colorectal Neoplasms (pathology)</term>
<term>Disease-Free Survival</term>
<term>Drug Resistance, Neoplasm</term>
<term>Female</term>
<term>Fluorouracil (therapeutic use)</term>
<term>Gene Frequency</term>
<term>Genetic Association Studies</term>
<term>Humans</term>
<term>Kaplan-Meier Estimate</term>
<term>Leucovorin (therapeutic use)</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Polymorphism, Single Nucleotide</term>
<term>Proteolysis</term>
<term>Receptor, Epidermal Growth Factor (metabolism)</term>
<term>Treatment Outcome</term>
<term>Ubiquitin-Conjugating Enzymes (genetics)</term>
<term>Ubiquitination</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="analogs & derivatives" xml:lang="en"><term>Camptothecin</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Ubiquitin-Conjugating Enzymes</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Receptor, Epidermal Growth Factor</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Antineoplastic Agents</term>
<term>Cetuximab</term>
</keywords>
<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Adenocarcinoma</term>
<term>Colorectal Neoplasms</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Adenocarcinoma</term>
<term>Colorectal Neoplasms</term>
</keywords>
<keywords scheme="MESH" qualifier="mortality" xml:lang="en"><term>Adenocarcinoma</term>
<term>Colorectal Neoplasms</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Colorectal Neoplasms</term>
</keywords>
<keywords scheme="MESH" qualifier="secondary" xml:lang="en"><term>Adenocarcinoma</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antineoplastic Agents</term>
<term>Antineoplastic Combined Chemotherapy Protocols</term>
<term>Camptothecin</term>
<term>Cetuximab</term>
<term>Fluorouracil</term>
<term>Leucovorin</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adult</term>
<term>Aged</term>
<term>Aged, 80 and over</term>
<term>Case-Control Studies</term>
<term>Disease-Free Survival</term>
<term>Drug Resistance, Neoplasm</term>
<term>Female</term>
<term>Gene Frequency</term>
<term>Genetic Association Studies</term>
<term>Humans</term>
<term>Kaplan-Meier Estimate</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Polymorphism, Single Nucleotide</term>
<term>Proteolysis</term>
<term>Treatment Outcome</term>
<term>Ubiquitination</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p id="P1">Transmembrane receptors such as the epidermal growth factor receptor (EGFR) are regulated by their turnover, which is dependent on the ubiquitin-proteasome-system (UPS). We tested in two independent study cohorts whether single nucleotide polymorphisms (SNPs) in genes involved in EGFR turnover predict clinical outcome in cetuximab treated metastatic colorectal cancer patients. The following SNPs involved in EGFR degradation were analyzed in a screening cohort of 108 patients treated with cetuximab in the chemorefractory setting: <italic>c-CBL</italic>
 (rs7105971; rs4938637; rs4938638; rs251837), <italic>EPS15</italic>
 (rs17567; rs7308; rs1065754), <italic>NAE1</italic>
 (rs363169; rs363170; rs363172); <italic>SH3KBP1</italic>
 (rs7051590; rs5955820; rs1017874; rs11795873); <italic>SGIP1</italic>
 (rs604737; rs6570808; rs7526812); <italic>UBE2M</italic>
 (rs895364; rs895374); <italic>UBE2L3</italic>
 (rs5754216). SNPs showing an association with response or survival were analyzed in BRAF and RAS wild-type samples from the FIRE-3 study. 153 FOLFIRI plus cetuximab treated patients served as validation set, 168 patients of the FOLFIRI plus bevacizumab arm served as controls. EGFR FISH was done in 138 samples to test whether significant SNPs were associated with EGFR expression. <italic>UBE2M</italic>
 rs895374 was significantly associated with PFS (logrank-p = 0.005; HR 0.60) within cetuximab treated patients. No association with bevacizumab treated patients (n=168) could be established (p= 0.56, HR: 0.90). rs895374 genotype did not affect EGFR FISH measurements. EGFR recycling is an interesting mechanism of secondary resistance to cetuximab in mCRC. This is the first report suggesting that germline polymorphisms in the degradation process predict efficacy of cetuximab in patients with mCRC. Genes involved in EGFR turnover may be new targets in the treatment of mCRC.</p>
</div>
</front>
</TEI>
<affiliations><list><country><li>Allemagne</li>
<li>Autriche</li>
<li>Espagne</li>
<li>Italie</li>
<li>États-Unis</li>
</country>
<region><li>Bade-Wurtemberg</li>
<li>Bavière</li>
<li>Californie</li>
<li>Catalogne</li>
<li>District de Haute-Bavière</li>
<li>District de Karlsruhe</li>
<li>Toscane</li>
</region>
<settlement><li>Barcelone</li>
<li>Heidelberg</li>
<li>Munich</li>
<li>Pise</li>
</settlement>
<orgName><li>Université Louis-et-Maximilien de Munich</li>
</orgName>
</list>
<tree><noCountry><name sortKey="Matsusaka, Satoshi" sort="Matsusaka, Satoshi" uniqKey="Matsusaka S" first="Satoshi" last="Matsusaka">Satoshi Matsusaka</name>
<name sortKey="Ning, Yan" sort="Ning, Yan" uniqKey="Ning Y" first="Yan" last="Ning">Yan Ning</name>
<name sortKey="Stremitzer, Stefan" sort="Stremitzer, Stefan" uniqKey="Stremitzer S" first="Stefan" last="Stremitzer">Stefan Stremitzer</name>
<name sortKey="Sunakawa, Yu" sort="Sunakawa, Yu" uniqKey="Sunakawa Y" first="Yu" last="Sunakawa">Yu Sunakawa</name>
<name sortKey="Yamauchi, Shinichi" sort="Yamauchi, Shinichi" uniqKey="Yamauchi S" first="Shinichi" last="Yamauchi">Shinichi Yamauchi</name>
<name sortKey="Zhang, Wu" sort="Zhang, Wu" uniqKey="Zhang W" first="Wu" last="Zhang">Wu Zhang</name>
</noCountry>
<country name="Allemagne"><region name="Bavière"><name sortKey="Stintzing, Sebastian" sort="Stintzing, Sebastian" uniqKey="Stintzing S" first="Sebastian" last="Stintzing">Sebastian Stintzing</name>
</region>
<name sortKey="Folwaczny, Matthias" sort="Folwaczny, Matthias" uniqKey="Folwaczny M" first="Matthias" last="Folwaczny">Matthias Folwaczny</name>
<name sortKey="Heinemann, Volker" sort="Heinemann, Volker" uniqKey="Heinemann V" first="Volker" last="Heinemann">Volker Heinemann</name>
<name sortKey="Heinemann, Volker" sort="Heinemann, Volker" uniqKey="Heinemann V" first="Volker" last="Heinemann">Volker Heinemann</name>
<name sortKey="Jung, Andreas" sort="Jung, Andreas" uniqKey="Jung A" first="Andreas" last="Jung">Andreas Jung</name>
<name sortKey="Kemmerling, Ralf" sort="Kemmerling, Ralf" uniqKey="Kemmerling R" first="Ralf" last="Kemmerling">Ralf Kemmerling</name>
<name sortKey="Kirchner, Thomas" sort="Kirchner, Thomas" uniqKey="Kirchner T" first="Thomas" last="Kirchner">Thomas Kirchner</name>
<name sortKey="Kirchner, Thomas" sort="Kirchner, Thomas" uniqKey="Kirchner T" first="Thomas" last="Kirchner">Thomas Kirchner</name>
</country>
<country name="Autriche"><noRegion><name sortKey="Neureiter, Daniel" sort="Neureiter, Daniel" uniqKey="Neureiter D" first="Daniel" last="Neureiter">Daniel Neureiter</name>
</noRegion>
<name sortKey="Kemmerling, Ralf" sort="Kemmerling, Ralf" uniqKey="Kemmerling R" first="Ralf" last="Kemmerling">Ralf Kemmerling</name>
</country>
<country name="États-Unis"><region name="Californie"><name sortKey="Yang, Dongyun" sort="Yang, Dongyun" uniqKey="Yang D" first="Dongyun" last="Yang">Dongyun Yang</name>
</region>
<name sortKey="Lenz, Heinz Josef" sort="Lenz, Heinz Josef" uniqKey="Lenz H" first="Heinz-Josef" last="Lenz">Heinz-Josef Lenz</name>
</country>
<country name="Espagne"><region name="Catalogne"><name sortKey="Sebio, Ana" sort="Sebio, Ana" uniqKey="Sebio A" first="Ana" last="Sebio">Ana Sebio</name>
</region>
</country>
<country name="Italie"><region name="Toscane"><name sortKey="Loupakis, Fotios" sort="Loupakis, Fotios" uniqKey="Loupakis F" first="Fotios" last="Loupakis">Fotios Loupakis</name>
</region>
<name sortKey="Cremolini, Chiara" sort="Cremolini, Chiara" uniqKey="Cremolini C" first="Chiara" last="Cremolini">Chiara Cremolini</name>
<name sortKey="Falcone, Alfredo" sort="Falcone, Alfredo" uniqKey="Falcone A" first="Alfredo" last="Falcone">Alfredo Falcone</name>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Rhénanie/explor/UnivTrevesV1/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000239 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000239 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Rhénanie
   |area=    UnivTrevesV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     PMC:4596768
   |texte=   Polymorphisms in genes involved in EGFR-turnover are predictive for cetuximab efficacy in colorectal cancer
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i   -Sk "pubmed:26206335" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd   \
       | NlmPubMed2Wicri -a UnivTrevesV1

This area was generated with Dilib version V0.6.31.
Data generation: Sat Jul 22 16:29:01 2017. Site generation: Wed Feb 28 14:55:37 2024

Serveur d'exploration sur l'Université de Trèves

Polymorphisms in genes involved in EGFR-turnover are predictive for cetuximab efficacy in colorectal cancer

Polymorphisms in genes involved in EGFR-turnover are predictive for cetuximab efficacy in colorectal cancer

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

	Serveur d'exploration sur l'Université de Trèves
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.